Polynucleotides (PDRN / PRDN) for the face — Plinest, Newest, PhilArt FACE

PDRN: Plinest · Newest · PhilArt Exosomes: ExoCoBio · Benev Course of 3–4 sessions Combined

Polynucleotides vs exosomes — what to choose in Baku

The two most discussed regenerative procedures of 2025–2026. Polynucleotides (PDRN) — DNA fragments from salmon, activate your own fibroblasts through A2A receptors. Exosomes — nanovesicles from stem cells with ready-made growth factors and microRNA. Different molecules, different mechanisms — and they are often combined rather than opposed.

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A brief comparison

Paramed

Polynucleotides and exosomes are both procedures related to regenerative medicine, but they are different molecules with fundamentally different mechanisms. Polynucleotides (PDRN — polydeoxyribonucleotide; synonym: PRDN) are purified DNA fragments from salmon or trout. They bind to A2A adenosine receptors on your fibroblasts and activate their own collagen synthesis. Exosomes are nanovesicles 30–150 nm, derived from adipose-derived stem cells (ADSC) or umbilical stem cells. They carry ready-made growth factors (TGF-β, VEGF, EGF, FGF), cytokines, and microRNA — and “reprogram” skin cells. These procedures are often prescribed sequentially or combined: PDRN for the structure and density of the dermis, exosomes for regeneration and anti-inflammatory effects (especially after laser treatments). There are contraindications; consultation is required.

When to choose what

Paramed

If the main concern is thin skin under the eyes, dark circles from vessels, atrophy after prolonged photoaging, or you want to specifically 'improve skin quality' — start with PDRN (PhilArt EYE / Plinest / Newest). If the skin is fine in density but there was aggressive laser treatment, there is post-acne with inflammation, or you want a quick 'wow' effect in radiance — choose exosomes (ExoCoBio ASCE+ or Benev). For complex requests — for example, overall facial rejuvenation with couperose — the doctor often combines: the first 2 sessions of PDRN for structure, then 2 sessions of exosomes after microneedling. Also, exosomes are the gold standard immediately after CO2 laser or PiCO/Megapixel.

Different molecules, different mechanisms

Paramed

Polynucleotides are long chains of nucleotides 50–1500 kDa from trout/salmon DNA. After injection into the dermis, they break down into short fragments and bind to A2A receptors on fibroblasts and keratinocytes. This activates the synthesis of collagen types I and III, fibroblast migration, and angiogenesis — the growth of new capillaries. The effect is cumulative: visible density and skin quality increase 2–3 months after the course. Exosomes are nanovesicles from stem cells, packed with signaling molecules. They penetrate skin cells and deliver ready-made growth factors and microRNA, activating Wnt/β-catenin pathways and suppressing inflammation. The effect is more “instantaneous” in terms of radiance and regeneration, especially after aggressive procedures.

PDRN: DNA fragments → activate your fibroblasts through A2A
Exosomes: nanovesicles from stem cells → carry growth factors
PDRN: structural effect, cumulative (2–3 months)
Exosomes: regenerative effect, visible sooner (1–4 weeks)
PDRN is better for thin skin under the eyes, atrophy
Exosomes are better after laser treatments and in cases of significant inflammation

FAQ

Paramed

? Which is better — polynucleotides or exosomes? ⌄

These are different procedures for different tasks. PDRN is better for skin density and structure, especially under the eyes and in cases of atrophy. Exosomes are better for regeneration after laser treatments and in cases with inflammatory components (post-acne, rosacea). Often, the doctor prescribes both in one program.

? Can PDRN and exosomes be done in one course? ⌄

Yes, this is a common combination. Usually, 2 sessions of PDRN with an interval of 2–3 weeks for structure, followed by 2 sessions of exosomes after microneedling for regeneration. The exact order and intervals are determined by the doctor.

? Which lasts longer? ⌄

The effect of PDRN on skin density and quality lasts 6–9 months. Exosomes last 3–6 months. Both require maintenance sessions.

? Which is cheaper? ⌄

Basic PDRN protocols (Pluryal Silk) start from 320 AZN. Basic exosomes start from 350 AZN. Premium options for PDRN (Newest) and exosomes (ExoCoBio ASCE+ SRLV) range from 420 to 550 AZN.

? Are there common contraindications? ⌄

Pregnancy, lactation, oncology, autoimmune diseases in active phase, blood clotting disorders, skin infections. For PDRN, additionally — severe allergy to fish/seafood.

Booking

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Ready to start?

Schedule a consultation at Paramed — the doctor will assess your skin condition and select a protocol: polynucleotides, exosomes, or their combination in one program.

PDRN and exosomes — pros and cons

Paramed

Polynucleotides (PDRN — Plinest, Newest, PhilArt, Pluryal Silk)

Pros

Rebuild the structure of the dermis — density, elasticity
Work effectively on thin skin under the eyes (PhilArt EYE)
Stimulate your own fibroblasts
Cumulative effect — increases over 2–3 months
Compatible with fillers and Botox in one program
Price is lower than premium exosomes

Cons

The effect is not 'instant' — takes 2–3 months
Less effective after laser treatments compared to exosomes
Contraindicated in severe allergies to fish/seafood
Not suitable for acute inflammation and regeneration

Exosomes (ExoCoBio ASCE+ SRLV, Exomage, BENEV)

Pros

Ready-made growth factors — rapid regenerative effect
Ideal immediately after laser/microneedling
Strong anti-inflammatory profile (especially Exomage)
Radiance and tone improvement visible within 1–2 weeks
Standardized dosage

Cons

More expensive than PDRN with comparable protocols
Less effective specifically for density and quality of structure
Effect is less long-lasting without support
For deep regeneration — better in conjunction with microneedling/laser

Polynucleotides (PDRN / PRDN)

Paramed

AZN Polynucleotides (PDRN / PRDN)

Service

Price

Polynucleotides (PDRN / PRDN) — Plinest (Mastelli, Italy)

Original Italian PDRN from trout DNA. Skin booster for density and skin quality.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Newest (Mastelli)

Reinforced Plinest formula for mature skin and areas with marked atrophy.

420–480 AZN

Polynucleotides (PDRN / PRDN) — PhilArt EYE (under-eye)

Korea, Croma-Pharma. Special formula for thin under-eye skin — dark circles, wrinkles, thinning.

350–420 AZN

Polynucleotides (PDRN / PRDN) — PhilArt FACE

Standard face protocol: density, tone, post-acne, early signs of aging.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Pluryal Silk

Switzerland, MD Skin Solutions. Accessible option for basic protocols and maintenance.

320–380 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Medium (Medixa, Italy)

PDRN 20 mg/ml + hyaluronic acid. Skin density and firmness, medium wrinkles and scars.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Strong (Medixa, Italy)

PDRN 25 mg/ml + hyaluronic acid 2 mg/ml. Deep regeneration: face, neck, décolletage, hands, body.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran Healer (PharmaResearch, Korea)

Pure polynucleotides from salmon DNA (DOT™). Flagship for all-round anti-aging, density and skin quality.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran I (under-eye) (PharmaResearch, Korea)

Formula for the periorbital area: dark circles, thin skin, under-eye wrinkles.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Rejuran S (PharmaResearch, Korea)

High viscosity, for post-acne scars and deep skin damage.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran HB (PharmaResearch, Korea)

Polynucleotides + non-crosslinked hyaluronic acid. Hydration with less discomfort, good for a first course.

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc 1.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, entry concentration. Biorevitalisation and skin quality.

320–380 AZN

Polynucleotides (PDRN / PRDN) — TwAc 2.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, reinforced formula. Density and tone across all skin layers.

350–420 AZN

Polynucleotides (PDRN / PRDN) — TwAc 3.0 (Yuma Medical, UK)

PDRN 10 mg/ml + hyaluronic acid 20 mg/ml. Deformational aging, hands, décolletage (30+).

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc Eyes (under-eye) (Yuma Medical, UK)

PDRN + hyaluronic acid for the under-eye area: dark circles, puffiness, fine lines.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Elare Red PN (U-Skin Lab, Korea)

Korea, U-Skin Lab. Salmon-DNA polynucleotide skin booster. Density, tone and quality of facial skin.

350–420 AZN

Polynucleotides (PDRN / PRDN) for hair — PhilArt SCALP

Korea, Croma-Pharma. Specialized scalp protocol: microcirculation, hair thickening.

300–380 AZN

Polynucleotides (PDRN / PRDN) for hair — Plinest (Mastelli)

Italian PDRN, off-label scalp protocol. Often paired with mesotherapy and PRP.

320–400 AZN

Polynucleotides (PDRN) — ADN Restart 2% (Mesopharm)

Russia, Mesopharm. Sodium deoxyribonucleotide 2% (salmon-milt DNA fragments under 450 kDa) with tripeptide-1 and a pH 7.0 buffer, 4 ml vial. Repair and anti-ageing work; delivered by injection.

$$$

Polynucleotides (PDRN) — NucleoSpire DNA-RNA 2% (Mesopharm)

Russia, Mesopharm. Polynucleotides at 20 mg/ml (2%) as salmon-milt DNA-RNA complexes plus non-stabilised hyaluronic acid 0.3%, in 1.3 ml and 4 ml vials. Intensive revitalisation, pigmentation work and recovery after aggressive procedures.

$$$

Polynucleotides (PDRN) — POLY-N Strong (Italy)

Italy. A polynucleotide gel at 25 mg/ml in a 2 ml syringe — one of the highest PDRN concentrations on the market. Mobilises fibroblasts to rebuild collagen and elastin; for marked loss of density and skin quality.

$$$