Polynucleotides (PDRN / PRDN) for the face — Plinest, Newest, PhilArt FACE

PDRN: Plinest · Newest · PhilArt Exosomes: ExoCoBio · Benev Course of 3–4 sessions Combined

Polynucleotides vs exosomes — what to choose in Baku

The two most discussed regenerative procedures of 2025–2026. Polynucleotides (PDRN) — DNA fragments from salmon, activate your own fibroblasts through A2A receptors. Exosomes — nanovesicles from stem cells with ready-made growth factors and microRNA. Different molecules, different mechanisms — and they are often combined rather than opposed.

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A brief comparison

Paramed

Polynucleotides and exosomes are both procedures related to regenerative medicine, but they are different molecules with fundamentally different mechanisms. Polynucleotides (PDRN — polydeoxyribonucleotide; synonym: PRDN) are purified DNA fragments from salmon or trout. They bind to A2A adenosine receptors on your fibroblasts and activate their own collagen synthesis. Exosomes are nanovesicles 30–150 nm, derived from adipose-derived stem cells (ADSC) or umbilical stem cells. They carry ready-made growth factors (TGF-β, VEGF, EGF, FGF), cytokines, and microRNA — and “reprogram” skin cells. These procedures are often prescribed sequentially or combined: PDRN for the structure and density of the dermis, exosomes for regeneration and anti-inflammatory effects (especially after laser treatments). There are contraindications; consultation is required.

When to choose what

Paramed

If the main concern is thin skin under the eyes, dark circles from vessels, atrophy after prolonged photoaging, or you want to specifically 'improve skin quality' — start with PDRN (PhilArt EYE / Plinest / Newest). If the skin is fine in density but there was aggressive laser treatment, there is post-acne with inflammation, or you want a quick 'wow' effect in radiance — choose exosomes (ExoCoBio ASCE+ or Benev). For complex requests — for example, overall facial rejuvenation with couperose — the doctor often combines: the first 2 sessions of PDRN for structure, then 2 sessions of exosomes after microneedling. Also, exosomes are the gold standard immediately after CO2 laser or PiCO/Megapixel.

Different molecules, different mechanisms

Paramed

Polynucleotides are long chains of nucleotides 50–1500 kDa from trout/salmon DNA. After injection into the dermis, they break down into short fragments and bind to A2A receptors on fibroblasts and keratinocytes. This activates the synthesis of collagen types I and III, fibroblast migration, and angiogenesis — the growth of new capillaries. The effect is cumulative: visible density and skin quality increase 2–3 months after the course. Exosomes are nanovesicles from stem cells, packed with signaling molecules. They penetrate skin cells and deliver ready-made growth factors and microRNA, activating Wnt/β-catenin pathways and suppressing inflammation. The effect is more “instantaneous” in terms of radiance and regeneration, especially after aggressive procedures.

PDRN: DNA fragments → activate your fibroblasts through A2A
Exosomes: nanovesicles from stem cells → carry growth factors
PDRN: structural effect, cumulative (2–3 months)
Exosomes: regenerative effect, visible sooner (1–4 weeks)
PDRN is better for thin skin under the eyes, atrophy
Exosomes are better after laser treatments and in cases of significant inflammation

FAQ

Paramed

? Which is better — polynucleotides or exosomes? ⌄

These are different procedures for different tasks. PDRN is better for skin density and structure, especially under the eyes and in cases of atrophy. Exosomes are better for regeneration after laser treatments and in cases with inflammatory components (post-acne, rosacea). Often, the doctor prescribes both in one program.

? Can PDRN and exosomes be done in one course? ⌄

Yes, this is a common combination. Usually, 2 sessions of PDRN with an interval of 2–3 weeks for structure, followed by 2 sessions of exosomes after microneedling for regeneration. The exact order and intervals are determined by the doctor.

? Which lasts longer? ⌄

The effect of PDRN on skin density and quality lasts 6–9 months. Exosomes last 3–6 months. Both require maintenance sessions.

? Which is cheaper? ⌄

Basic PDRN protocols (Pluryal Silk) start from 320 AZN. Basic exosomes start from 350 AZN. Premium options for PDRN (Newest) and exosomes (ExoCoBio ASCE+ SRLV) range from 420 to 550 AZN.

? Are there common contraindications? ⌄

Pregnancy, lactation, oncology, autoimmune diseases in active phase, blood clotting disorders, skin infections. For PDRN, additionally — severe allergy to fish/seafood.

Booking

Paramed

Ready to start?

Schedule a consultation at Paramed — the doctor will assess your skin condition and select a protocol: polynucleotides, exosomes, or their combination in one program.

PDRN and exosomes — pros and cons

Paramed

Polynucleotides (PDRN — Plinest, Newest, PhilArt, Pluryal Silk)

Pros

Rebuild the structure of the dermis — density, elasticity
Work effectively on thin skin under the eyes (PhilArt EYE)
Stimulate your own fibroblasts
Cumulative effect — increases over 2–3 months
Compatible with fillers and Botox in one program
Price is lower than premium exosomes

Cons

The effect is not 'instant' — takes 2–3 months
Less effective after laser treatments compared to exosomes
Contraindicated in severe allergies to fish/seafood
Not suitable for acute inflammation and regeneration

Exosomes (ExoCoBio ASCE+ SRLV, Exomage, BENEV)

Pros

Ready-made growth factors — rapid regenerative effect
Ideal immediately after laser/microneedling
Strong anti-inflammatory profile (especially Exomage)
Radiance and tone improvement visible within 1–2 weeks
Standardized dosage

Cons

More expensive than PDRN with comparable protocols
Less effective specifically for density and quality of structure
Effect is less long-lasting without support
For deep regeneration — better in conjunction with microneedling/laser

Injections — mesotherapy & biorevitalization

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AZN Injections — mesotherapy & biorevitalization

Service

Price

PRP

Patient's autologous plasma with platelet concentrate. Universal rejuvenation of face, neck and hands; stimulates hair growth.

80 AZN

INNEA Aqua

Italy, Matex Lab. Biorevitalizer based on natural hyaluronic acid. Deep hydration, barrier restoration and skin radiance; suitable for all skin types and first-time biorevitalization.

200 AZN

Aquashine BR

Korea, Caregen. HA + 5 peptides, brightening profile. Biorevitalization for pigmentation, dull skin and uneven tone.

200 AZN

Aquashine PTX

Korea, Caregen. HA + peptides + polynucleotides. Enhanced anti-aging formula for mature skin and density.

220 AZN

Jalupro HMW

Switzerland, Professional Derma. High-molecular-weight HA + 4 amino acids (glycine, proline, lysine, leucine). Deep densification and fibroblast stimulation.

200 AZN

Restylane Vital

Sweden, Galderma. Stabilized HA via NASHA technology. Premium biorevitalization benchmark; course effect lasts up to 6 months.

300 AZN

Novacutan (Y-Bio / S-Bio)

Germany, Adoderm. Premium biorevitalization: Y-Bio (HA + 4 amino acids) or S-Bio (HA + succinic acid). Deep densification and anti-aging for face 35+. Course of 3–5 sessions.

340 AZN

Hyalual 1.1%

Switzerland, Hyalual Institute. HA + succinic acid, entry 1.1% concentration. For sensitive skin and first-time biorevitalization.

180 AZN

Hyalual 1.8%

Switzerland, Hyalual Institute. Universal 1.8% concentration — HA + succinic acid. Standard biorevitalization for face 30+.

200 AZN

Hyalual 2.2%

Switzerland, Hyalual Institute. Maximum 2.2% HA concentration with succinic acid. Pronounced densification and anti-aging for mature skin.

230 AZN

Teosyal PureSense Redensity I

Switzerland, Teoxane. HA + 8 amino acids + 3 antioxidants + vitamin B6 + lidocaine. Biorevitalization cocktail with built-in anaesthetic for face 25–35.

250 AZN

Jalupro

Switzerland, Professional Derma. Classic HA + 4 amino acids. Base biorevitalization protocol for face 25+.

180 AZN

NCTF 135 (3 ml)

France, Filorga. 53 active ingredients — vitamins, amino acids, antioxidants, minerals, coenzymes. Classic mesotherapy for dull and dehydrated skin.

150 AZN

NCTF 135 HA (3 ml)

France, Filorga. NCTF 135 + free hyaluronic acid. Enhanced hydration combined with the full nutrient complex.

180 AZN

Dermaheal Meso HSR

Korea, Caregen. Healthy Skin Recovery — anti-aging cocktail with growth factors and peptides. Smoothness and tone for face 30+.

60 AZN

Dermaheal Meso SB

Korea, Caregen. Skin Brightening — lightening cocktail with glutathione and kojic acid. For pigmentation, melasma and dull skin.

60 AZN

Dermaheal Eyebag Solution

Korea, Caregen. Targeted cocktail for under-eye bags and puffiness. Caffeine and peptides, drainage effect.

100 AZN

Dermaheal Dark Circle Solution

Korea, Caregen. Targeted cocktail for dark under-eye circles — addresses hemosiderin and pigmentation in thin skin.

100 AZN

Dermaheal HL

Korea, Caregen. Hair Loss — scalp mesotherapy. Against hair fall, for growth stimulation and density.

60 AZN

Lipolax — lipolytic (Korea)

Korea, Lipolax. Injection lipolytic based on phosphatidylcholine + deoxycholic acid. Localised fat reduction: double chin, flanks, abdomen, knees. Course of 2–4 sessions spaced 2–3 weeks apart.

100 AZN

Lipolab — lipolytic (Caregen, Korea)

Korea, Caregen Lipolab (PPC). Phosphatidylcholine-based injection lipolytic — disrupts fat-cell membranes. Target zones: double chin, flanks, banana fold, small localised fat deposits. Course of 2–4 sessions.

100 AZN

Exosomes for face — ExoCoBio ASCE+ SRLV

Premium flagship. Used in Oracle, Wonjin, Banobagi after laser resurfacing and microneedling.

480–550 AZN

Exosomes for face — ExoCoBio Exomage (sensitive skin, rosacea)

Anti-inflammatory profile; for rosacea, couperose and reactive skin.

500–580 AZN

Exosomes for face — BENEV

Premium; umbilical cord stem cell exosomes. Standard microneedling and RF partner.

450–520 AZN

Exosomes for face — standard kit

Accessible option for basic protocols and maintenance courses.