
Elvira Zakiyeva
Cosmetologist (MD)
15+ years' experience
2008 · Azerbaijan Medical University · +1 cert.
Languages: Russian, Azerbaijani

A Korean exosome product for the scalp: 10 billion particles per vial, a hybrid formula of mesenchymal stem cell exosomes and plant vesicles, growth factors and peptides.
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Zishel Xomage H is made by the Korean company Zishel Medical as part of its XOMAGE line and is formulated for the scalp. One vial holds 100 mg of dry substance and a declared 10 billion particles: a hybrid formula in which exosomes from adipose-derived mesenchymal stem cells (ADMSC) are combined with four types of plant extracellular vesicles. Five growth factors, a six-peptide complex, biotin and sodium hyaluronate are added on top. The manufacturer's indications are hair thinning, hair loss, growth-cycle disorders and scalp inflammation. The product is for in-clinic use only: it is applied through microneedling or delivered by mesotherapy.
The scalp is cleansed and disinfected, and topical anaesthetic is applied if needed. The product is reconstituted immediately before use and distributed across the thinning zones: either through microneedling along standard directions, or by mesotherapy — micro-injections into the dermis. The session takes 30–40 minutes. It ends with a soothing product; do not wash your hair for 24 hours.
Exosome therapy on the scalp is not about "feeding" the hair — it is about signalling to the follicle: vesicles carry growth factors and microRNA that influence the follicle's shift into anagen and the state of its microenvironment — inflammation, microcirculation, the dermal papilla. Xomage H combines two vesicle sources: ADMSC exosomes provide the main regenerative signal, while plant extracellular vesicles act as an additional carrier for actives and as antioxidant support. A distinctive feature of the XOMAGE line is traceability: every lot carries a QR code with data on its origin and manufacturing conditions — which, for this class of product, matters more than any marketing claim.
In the price list this item is marked "$$$" — we quote it at consultation, because the cost depends on how many vials a session takes and on the protocol (exosomes alone, or combined with microneedling and mesotherapy). You can get the exact figure on WhatsApp.
The formula is adapted to the scalp: the emphasis is on biotin, the peptide complex and growth factors that act on the follicle. The skin version (Xomage) addresses different goals — tone, density and skin quality.
It depends on the technique. With microneedling we use topical anaesthetic and discomfort is moderate. Scalp mesotherapy feels like a series of short pricks; the session takes 30–40 minutes.
Usually 4 at 2–4 week intervals, then maintenance. The exact number depends on the stage of hair loss and its cause, which we establish with trichoscopy and blood work.
No. In AGA they are part of a combined plan, not a substitute for the baseline therapy your doctor prescribes. Exosomes improve hair quality and density but do not remove the cause — which is why we start with diagnostics.
Book a trichology consultation — the doctor will run a trichoscopy, identify the cause of your hair loss and tell you whether exosomes or a different protocol is the right call.
Book a consultation →The standard schedule is 4 sessions at 2–4 week intervals, followed by maintenance sessions as your doctor advises (usually every 1.5–2 months). The first change you notice is rarely "new hair" — it is less shedding: fewer hairs on the brush and in the shower. New growth is assessed on trichoscopy after 3–4 months, which is simply how long the hair cycle takes; there is no objective progress to measure sooner.
Compared with ExoCoBio ASCE for hair and BENEV, Xomage H is close to ASCE in particle count (10 billion) but differs in its hybrid composition — plant vesicles are not used in the other kits. Promoitalia's ExoSignal™ Hair is built on a different principle: a synthetic exosomal structure plus a high concentration of PDRN, which makes it a different class of product. PRP remains the more affordable option based on your own plasma, but it does not deliver a defined set of growth factors and peptides. The honest framing: in androgenetic alopecia no exosome product replaces baseline therapy — it reinforces it and works as part of a plan built after diagnostics; and in scarring alopecia lost follicles do not come back.
At Paramed, hair work always starts with diagnostics: trichoscopy and, where needed, blood work — ferritin, vitamin D, thyroid hormones. Only then do we discuss the product: sometimes it makes more sense to start with baseline therapy and mesotherapy and add exosomes later. We store Xomage H under controlled conditions and track expiry dates; the lot can be verified through the manufacturer's QR code. If your doctor thinks polynucleotides or PRP would work better in your case, they will say so directly.
Certified specialists at Paramed

Cosmetologist (MD)
15+ years' experience
2008 · Azerbaijan Medical University · +1 cert.
Languages: Russian, Azerbaijani

Cosmetologist (MD)
2019 · Yaroslavl Medical University · +1 cert.
Languages: Russian, Azerbaijani

Dermatologist (MD)
2017 · Donetsk National Medical University · +1 cert.
Languages: Russian, Azerbaijani