NucleoSpire DNA-RNA 2% — polynucleotides with hyaluronic acid, Paramed Baku

Mesopharm Polynucleotides 20 mg/ml DNA-RNA complexes HA 0.3% included Price on consultation

NucleoSpire DNA-RNA 2% — polynucleotides with hyaluronic acid in Baku

A Mesopharm biorevitalisant built on DNA-RNA complexes: polynucleotides at 20 mg/ml together with non-stabilised hyaluronic acid at 0.3%. Vials of 1.3 ml and 4 ml — for the under-eye area and for the full face.

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Overview

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NucleoSpire DNA-RNA 2% is Mesopharm's product in which polynucleotides come paired with hyaluronic acid. The active sits at 20 mg/ml (2%) as salmon-milt DNA-RNA complexes, with non-stabilised biosynthetic hyaluronic acid at 0.3% and a buffer system. It comes in 1.3 ml and 4 ml vials, which covers both a small delicate area and the whole face. The main indications are intensive revitalisation, age-related change, pigmentation and skin recovery after aggressive procedures. Contraindications apply and a specialist consultation is required.

Benefits

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✅ Density and firmness
✅ Strong hydration from the HA
✅ Works on dullness and uneven tone
✅ Recovery after lasers and peels
✅ Comfortable to place
✅ Suits the periorbital area

How it works

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The skin is cleansed and disinfected, with numbing cream where needed. The product is placed by microinjections into the mid-dermis; the periorbital area gets a gentler technique and a smaller volume. The session takes 30–40 minutes and finishes with a soothing product and SPF.

Technology

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What separates it from pure polynucleotides is the added hyaluronic acid. Non-stabilised HA creates no volume: it holds water and makes the product spread more comfortably, which in practice softens the sensation during treatment. The polynucleotides still do their job as material and signal for fibroblasts. The combination is particularly apt when skin has not only lost density but is dehydrated — typical after a summer, a course of acid peels or laser resurfacing. The 1.3 ml format suits the periorbital area; 4 ml covers face, neck and décolleté.

Mesopharm — the NucleoSpire line
Polynucleotides at 20 mg/ml (2%)
Salmon-milt DNA-RNA complexes
Non-stabilised HA at 0.3%
1.3 ml and 4 ml vials
Revitalisation, pigmentation, recovery

Preparation & aftercare

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Before the procedure

No aspirin or NSAIDs for 5–7 days (after agreeing it with your doctor)
No peels or sunbathing for 3 days
No alcohol for 24 hours
Do not come with active inflammation, herpes or an acute infection
Tell us about chronic conditions and allergies

After the procedure

Do not touch the injection points or apply make-up for the first 24 hours
Sauna, pool and sport after 3–5 days
SPF 30+ for at least two weeks
Other injectable procedures after 7–10 days
Drink enough water

FAQ

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? How does NucleoSpire differ from plain polynucleotides? ⌄

The added 0.3% hyaluronic acid. It creates no volume but increases hydration and makes the session more comfortable.

? Which vial do I need? ⌄

1.3 ml is usually used for the periorbital area, 4 ml for face, neck or décolleté. The doctor decides the volume at the consultation.

? Does it help with pigmentation? ⌄

It belongs inside a combined protocol: it improves skin quality and recovery, but without SPF — and device work where needed — pigment results will not hold.

? How many sessions are in a course? ⌄

Usually 3–4 at 2–3 week intervals, then maintenance every 4–6 months.

? Can it be done after laser treatment? ⌄

Yes, that is one of the indications — skin recovery after aggressive procedures. The doctor sets the interval.

Booking

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Polynucleotides (PDRN / PRDN)

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AZN Polynucleotides (PDRN / PRDN)

Service

Price

Polynucleotides (PDRN / PRDN) — Plinest (Mastelli, Italy)

Original Italian PDRN from trout DNA. Skin booster for density and skin quality.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Newest (Mastelli)

Reinforced Plinest formula for mature skin and areas with marked atrophy.

420–480 AZN

Polynucleotides (PDRN / PRDN) — PhilArt EYE (under-eye)

Korea, Croma-Pharma. Special formula for thin under-eye skin — dark circles, wrinkles, thinning.

350–420 AZN

Polynucleotides (PDRN / PRDN) — PhilArt FACE

Standard face protocol: density, tone, post-acne, early signs of aging.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Pluryal Silk

Switzerland, MD Skin Solutions. Accessible option for basic protocols and maintenance.

320–380 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Medium (Medixa, Italy)

PDRN 20 mg/ml + hyaluronic acid. Skin density and firmness, medium wrinkles and scars.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Strong (Medixa, Italy)

PDRN 25 mg/ml + hyaluronic acid 2 mg/ml. Deep regeneration: face, neck, décolletage, hands, body.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran Healer (PharmaResearch, Korea)

Pure polynucleotides from salmon DNA (DOT™). Flagship for all-round anti-aging, density and skin quality.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran I (under-eye) (PharmaResearch, Korea)

Formula for the periorbital area: dark circles, thin skin, under-eye wrinkles.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Rejuran S (PharmaResearch, Korea)

High viscosity, for post-acne scars and deep skin damage.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran HB (PharmaResearch, Korea)

Polynucleotides + non-crosslinked hyaluronic acid. Hydration with less discomfort, good for a first course.

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc 1.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, entry concentration. Biorevitalisation and skin quality.

320–380 AZN

Polynucleotides (PDRN / PRDN) — TwAc 2.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, reinforced formula. Density and tone across all skin layers.

350–420 AZN

Polynucleotides (PDRN / PRDN) — TwAc 3.0 (Yuma Medical, UK)

PDRN 10 mg/ml + hyaluronic acid 20 mg/ml. Deformational aging, hands, décolletage (30+).

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc Eyes (under-eye) (Yuma Medical, UK)

PDRN + hyaluronic acid for the under-eye area: dark circles, puffiness, fine lines.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Elare Red PN (U-Skin Lab, Korea)

Korea, U-Skin Lab. Salmon-DNA polynucleotide skin booster. Density, tone and quality of facial skin.

350–420 AZN

Polynucleotides (PDRN / PRDN) for hair — PhilArt SCALP

Korea, Croma-Pharma. Specialized scalp protocol: microcirculation, hair thickening.

300–380 AZN

Polynucleotides (PDRN / PRDN) for hair — Plinest (Mastelli)

Italian PDRN, off-label scalp protocol. Often paired with mesotherapy and PRP.

320–400 AZN

Polynucleotides (PDRN) — ADN Restart 2% (Mesopharm)

Russia, Mesopharm. Sodium deoxyribonucleotide 2% (salmon-milt DNA fragments under 450 kDa) with tripeptide-1 and a pH 7.0 buffer, 4 ml vial. Repair and anti-ageing work; delivered by injection.

$$$

Polynucleotides (PDRN) — NucleoSpire DNA-RNA 2% (Mesopharm)

Russia, Mesopharm. Polynucleotides at 20 mg/ml (2%) as salmon-milt DNA-RNA complexes plus non-stabilised hyaluronic acid 0.3%, in 1.3 ml and 4 ml vials. Intensive revitalisation, pigmentation work and recovery after aggressive procedures.

$$$

Polynucleotides (PDRN) — POLY-N Strong (Italy)

Italy. A polynucleotide gel at 25 mg/ml in a 2 ml syringe — one of the highest PDRN concentrations on the market. Mobilises fibroblasts to rebuild collagen and elastin; for marked loss of density and skin quality.

$$$

Course plan

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A standard course is 3–4 sessions at 2–3 week intervals, with maintenance every 4–6 months. Hydration shows after the first session; density and tone need the full course. For pigmentation the product belongs inside a combined protocol rather than as a standalone answer — sun protection, and device work where needed, remain the foundation.

Comparison

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Against ADN Restart 2% from the same maker the PDRN concentration is comparable, but NucleoSpire adds hyaluronic acid — more hydration and a softer feel. Against POLY-N Strong (25 mg/ml) the concentration is lower, but the 1.3 ml format allows careful work under the eyes. The logic is close to Rejuran HB: polynucleotides plus HA, differing in manufacturer and viscosity. The doctor chooses on the state of the skin, not on how a line is marketed.

Contraindications

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⚠️ Pregnancy and breastfeeding
⚠️ Allergy to fish and seafood or to the product's components
⚠️ Active-phase autoimmune disease
⚠️ Oncological disease
⚠️ Blood clotting disorders
⚠️ Active inflammation or herpes in the treatment area

Why Paramed

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At Paramed the choice between PDRN products is made after an examination: sometimes concentration matters more, sometimes the added hyaluronic acid and a more comfortable session. We explain the difference in plain language and say honestly when a course will not deliver what you are hoping for. The price for NucleoSpire is quoted at the consultation — it depends on vial size and the number of areas.