NAD⁺ mesotherapy and PDRN polynucleotides — comparison

PDRN: 320–480 AZN NAD⁺: price on request PDRN: dermal structure NAD⁺: tone and freshness

NAD⁺ mesotherapy vs polynucleotides (PDRN)

Polynucleotides work on the structure of the dermis: density, firmness, tissue quality. NAD⁺ mesotherapy works on how the skin looks — tone, freshness, 'fatigue'. These are different goals, not competitors.

Book a Treatment

Leave your contact details, and our specialist will contact you for a consultation and booking.

✅ Individual program selection
✅ Price clarification by areas
✅ Answers to all medical questions

By clicking 'Send', you consent to the processing of personal data in accordance with our privacy policy.

Overview

Paramed

Polynucleotides (PDRN/PRDN) are DNA fragments, most often from salmon roe, injected into the dermis to act as a biorepair agent: they improve tissue quality, density and firmness, and help with skin atrophy, thin under-eye skin and post-acne. These are Rejuran, Plinest, Newest, PhilArt, Pluryal Silk and TwAc. NAD⁺ mesotherapy is about something else: a coenzyme involved in cellular energy is delivered intradermally to support renewal where the skin looks tired and dull. Put simply: polynucleotides change the quality of the tissue itself, while NAD⁺ addresses how the skin looks. If your concern is density and structure, NAD⁺ will not solve it. Contraindications apply.

How to choose between them

Paramed

Go by how you describe your own concern. 'My skin is thin, vessels show through under the eyes, there are atrophic scars, the tissue is lax' — that is polynucleotides, and NAD⁺ is not an alternative there. 'My skin is basically fine but it looks tired, dull, without freshness' — that is the scenario where NAD⁺ mesotherapy is discussed. In practice many people arrive with the second description while examination shows the first is the real issue, which is why a consultation before choosing is essential. Combining is possible: a PDRN course for structure, NAD⁺ as an accent on tone.

Dermal biorepair versus cellular energy

Paramed

Polynucleotides form a gel matrix in the dermis, hold water and create a favourable environment for fibroblasts: hence the gain in density and firmness, the improvement in thin skin and the work on atrophic change. That is why PDRN is the standard answer for thin under-eye skin, atrophy, post-acne and general tissue laxity — not simply for glow. The NAD⁺ mechanism is different: the coenzyme participates in cellular energy production and antioxidant defense. Intradermal delivery is conceived as support for normal renewal processes. NAD⁺ does not build a matrix in the dermis and does not directly increase tissue density. The evidence base for PDRN is considerably broader; for intradermal NAD⁺ the data are still accumulating.

PDRN: DNA fragments, a gel matrix, an environment for fibroblasts
NAD⁺: a cellular-energy coenzyme
PDRN: density, firmness, tissue quality, atrophy
NAD⁺: dull tone, freshness, skin 'fatigue'
PDRN: the standard for thin under-eye skin and post-acne
PDRN: broader evidence; NAD⁺: data still accumulating

FAQ

Paramed

? Which for thin under-eye skin? ⌄

Polynucleotides. This is their core indication — Rejuran I, PhilArt EYE and TwAc Eyes were developed specifically for the periorbital area. NAD⁺ mesotherapy does not build up the structure of thin skin.

? Which is better for glow and freshness of tone? ⌄

Here NAD⁺ mesotherapy is closer to the goal: it is aimed specifically at tired, dull skin. Polynucleotides also improve how the skin looks, but their strength is density and tissue quality, and the effect develops more slowly.

? Which is more expensive? ⌄

Polynucleotides cost 320–480 AZN per session depending on the formulation. For NAD⁺ mesotherapy the price is quoted on request and depends on the formulation, areas and protocol.

? Which has stronger evidence? ⌄

Polynucleotides, by a considerable margin. There is extensive practice and research on PDRN. Evidence for the cosmetic effects of intradermal NAD⁺ is still developing, and we do not hide that.

? Can they be done together? ⌄

Yes, within one plan, but usually as separate treatments spaced apart rather than in a single session. Sequence and intervals are set by your doctor.

? Which for post-acne? ⌄

Polynucleotides. They work on tissue quality and atrophic change. For marked post-acne, microneedling, laser and exosomes are also discussed. NAD⁺ mesotherapy is not the decisive treatment here.

Let's establish what actually addresses your concern

Paramed

Let's establish what actually addresses your concern

Polynucleotides and NAD⁺ mesotherapy solve different problems, so the choice starts with an examination. At the consultation we will assess skin density, thickness and tone and recommend what genuinely works in your case.

Book your consultation →

NAD⁺ mesotherapy and polynucleotides — pros and cons

Paramed

NAD⁺ mesotherapy

Pros

Targeted work on skin 'fatigue' and dull tone
Superficial delivery, session 20–40 minutes
Minimal downtime
Face, under-eye area, neck, décolletage, hands
Fits well into a combination protocol

Cons

Clinical evidence is still developing
Does not address volume, laxity or deep wrinkles
Requires a course plus maintenance sessions
Price on request — depends on formulation and areas

PDRN polynucleotides (Rejuran, Plinest, Newest, PhilArt, TwAc)

Pros

Work on the structure and density of the dermis
The standard for thin under-eye skin
Help with skin atrophy and post-acne
The result holds for a long time after a course
Broad evidence base and extensive practice

Cons

Expensive — 320–480 AZN per session
Papules and swelling possible for a few days
Require a course of 2–4 sessions at 2–4 week intervals
Not the fastest treatment for glow — they work deeper and more slowly

Courses and frequency

Paramed

Polynucleotides run as a course of 2–4 sessions at 2–4 week intervals; the effect develops gradually and holds for a long time, with maintenance usually every 6–12 months. NAD⁺ mesotherapy runs as a course of several sessions followed by maintenance, with the protocol set at consultation. Neither treatment is designed for one-off use — a single session of either does not deliver a full result.

Polynucleotides (PDRN / PRDN)

Paramed

AZN Polynucleotides (PDRN / PRDN)

Service

Price

Polynucleotides (PDRN / PRDN) — Plinest (Mastelli, Italy)

Original Italian PDRN from trout DNA. Skin booster for density and skin quality.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Newest (Mastelli)

Reinforced Plinest formula for mature skin and areas with marked atrophy.

420–480 AZN

Polynucleotides (PDRN / PRDN) — PhilArt EYE (under-eye)

Korea, Croma-Pharma. Special formula for thin under-eye skin — dark circles, wrinkles, thinning.

350–420 AZN

Polynucleotides (PDRN / PRDN) — PhilArt FACE

Standard face protocol: density, tone, post-acne, early signs of aging.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Pluryal Silk

Switzerland, MD Skin Solutions. Accessible option for basic protocols and maintenance.

320–380 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Medium (Medixa, Italy)

PDRN 20 mg/ml + hyaluronic acid. Skin density and firmness, medium wrinkles and scars.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Strong (Medixa, Italy)

PDRN 25 mg/ml + hyaluronic acid 2 mg/ml. Deep regeneration: face, neck, décolletage, hands, body.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran Healer (PharmaResearch, Korea)

Pure polynucleotides from salmon DNA (DOT™). Flagship for all-round anti-aging, density and skin quality.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran I (under-eye) (PharmaResearch, Korea)

Formula for the periorbital area: dark circles, thin skin, under-eye wrinkles.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Rejuran S (PharmaResearch, Korea)

High viscosity, for post-acne scars and deep skin damage.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran HB (PharmaResearch, Korea)

Polynucleotides + non-crosslinked hyaluronic acid. Hydration with less discomfort, good for a first course.

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc 1.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, entry concentration. Biorevitalisation and skin quality.

320–380 AZN

Polynucleotides (PDRN / PRDN) — TwAc 2.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, reinforced formula. Density and tone across all skin layers.

350–420 AZN

Polynucleotides (PDRN / PRDN) — TwAc 3.0 (Yuma Medical, UK)

PDRN 10 mg/ml + hyaluronic acid 20 mg/ml. Deformational aging, hands, décolletage (30+).

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc Eyes (under-eye) (Yuma Medical, UK)

PDRN + hyaluronic acid for the under-eye area: dark circles, puffiness, fine lines.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Elare Red PN (U-Skin Lab, Korea)

Korea, U-Skin Lab. Salmon-DNA polynucleotide skin booster. Density, tone and quality of facial skin.

350–420 AZN

Polynucleotides (PDRN / PRDN) for hair — PhilArt SCALP

Korea, Croma-Pharma. Specialized scalp protocol: microcirculation, hair thickening.

300–380 AZN

Polynucleotides (PDRN / PRDN) for hair — Plinest (Mastelli)

Italian PDRN, off-label scalp protocol. Often paired with mesotherapy and PRP.

320–400 AZN

Polynucleotides (PDRN) — ADN Restart 2% (Mesopharm)

Russia, Mesopharm. Sodium deoxyribonucleotide 2% (salmon-milt DNA fragments under 450 kDa) with tripeptide-1 and a pH 7.0 buffer, 4 ml vial. Repair and anti-ageing work; delivered by injection.

$$$

Polynucleotides (PDRN) — NucleoSpire DNA-RNA 2% (Mesopharm)

Russia, Mesopharm. Polynucleotides at 20 mg/ml (2%) as salmon-milt DNA-RNA complexes plus non-stabilised hyaluronic acid 0.3%, in 1.3 ml and 4 ml vials. Intensive revitalisation, pigmentation work and recovery after aggressive procedures.

$$$

Polynucleotides (PDRN) — POLY-N Strong (Italy)

Italy. A polynucleotide gel at 25 mg/ml in a 2 ml syringe — one of the highest PDRN concentrations on the market. Mobilises fibroblasts to rebuild collagen and elastin; for marked loss of density and skin quality.

$$$

Contraindications — common to injectable treatments

Paramed

⚠️ Pregnancy and breastfeeding
⚠️ Active skin infection in the treatment area, herpes in an active phase
⚠️ Allergy to ingredients of the formulation
⚠️ A tendency toward abnormal scarring — keloid or hypertrophic scars
⚠️ Bleeding or clotting disorders, and anticoagulant use not cleared with your doctor
⚠️ Active malignancy

How we choose the treatment

Paramed

📍 Consultation first: we assess your skin and your primary concern
📍 We do not sell the fashionable treatment when a cheaper, more reliable one solves the problem
📍 We say plainly where the evidence is strong and where it is still developing
📍 All injectable treatments are performed by a physician, with traceable formulations
📍 A clinic in Baku — treatments can be combined into a single yearly plan