ExoSignal™ Hair (Promoitalia) — exosomal hair therapy in Baku
An Italian scalp product by Promoitalia: a synthetic exosomal structure plus high-molecular-weight PDRN, eight biomimetic peptides, plant stem cells and vitamins.
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Overview
ParamedExoSignal™ Hair belongs to the ExoSignal line by the Italian company Promoitalia and is formulated for the scalp. The ampoule holds 5 ml; a single session uses 1.5–2 ml. The formula is built on a synthetic exosomal structure that acts as a carrier for the actives, and on high-molecular-weight PDRN, which reduces inflammation and supports the cells of the dermal papilla. Added to that are eight biomimetic peptides selected specifically for the scalp, plant stem cells and vitamins for cellular metabolism, plus panthenol, glutathione, biotin and high-molecular-weight hyaluronic acid. It is applied transdermally with microneedling along the standard scalp directions.
Benefits
Paramed- ✅ Lower inflammatory load on the scalp
- ✅ Signalling stimulation of follicles and the growth phase
- ✅ Density and quality of newly growing hair
- ✅ Transdermal delivery through microneedling — no injection papules
- ✅ Fits well into a combined plan with mesotherapy and baseline therapy
How it works
ParamedThe scalp is cleansed and disinfected. 1.5–2 ml of product is spread evenly across the thinning zones and delivered transdermally with microneedling along the standard scalp directions, so the actives pass the stratum corneum. The session takes 30–40 minutes. It finishes with a soothing product; do not wash your hair for 24 hours.
Technology
ParamedExoSignal Hair belongs to the same family as the same manufacturer's V-Tech System, and that is worth knowing: this is a synthetic exosomal structure — a biomimetic carrier — not exosomes derived from human cells as in ExoCoBio or BENEV. The main active block here is high-molecular-weight PDRN plus a complex of eight biomimetic peptides aimed at stimulating the scalp. That composition works in two directions at once: it lowers the inflammatory load that often sustains hair loss, and it signals the follicle to move into an active growth phase. Glutathione and vitamins cover the antioxidant side, while biotin and panthenol support the quality of the hair and the scalp.
- Promoitalia — Italian manufacture, ExoSignal line
- 5 ml ampoule, 1.5–2 ml per session
- Synthetic exosomal structure — a carrier for the actives
- High-molecular-weight PDRN: anti-inflammatory action and papilla support
- 8 biomimetic peptides for the scalp
- Plant stem cells, vitamins, panthenol, glutathione, biotin, HA
- Course: at least 4 sessions at 10-day intervals, then maintenance every 2 months
Preparation & aftercare
Paramed- Wash your hair 12–24 hours before the session; no oils or styling products on the day
- Avoid aspirin and ibuprofen for 5–7 days (after clearing it with your doctor)
- No alcohol for 24 hours
- Do not come with inflammation, open lesions or a dermatitis flare on the scalp
- Bring your blood work and trichoscopy results if you already have them
- Do not wash your hair for 24 hours
- No hot blow-drying or styling products for a day
- Sauna, steam room, pool and intense workouts — after 3–5 days
- No hair colouring for 5–7 days
- Do not brush the area aggressively while it still feels tender
FAQ
Paramed? How much does ExoSignal Hair cost? ⌄
The item is marked "$$$" in the price list — the cost depends on how much product a session uses (1.5–2 ml depending on the thinning area) and on the protocol. We give the exact figure at consultation or on WhatsApp.
? Is it exosomes or not? ⌄
The manufacturer declares a synthetic exosomal structure — a biomimetic carrier for the actives. If you specifically want cell-derived exosomes, that is ExoCoBio ASCE, BENEV or Zishel Xomage H, which are separate items in the price list.
? How is it different from hair mesotherapy? ⌄
Mesotherapy cocktails work mostly nutritionally and through peptides. ExoSignal adds high-molecular-weight PDRN — an active with an anti-inflammatory and regenerative profile, the same class used in polynucleotide protocols.
? How many sessions are needed? ⌄
At least 4 at 10-day intervals, then maintenance every 2 months. With pronounced hair loss the course may be longer — trichoscopy decides.
? My hair sheds more after the first sessions — is that normal? ⌄
A short-term increase in shedding at the start of a course does happen: some telogen hairs let go and free up the follicle. If shedding intensifies and lasts more than 3–4 weeks, you need to be seen — that is a reason to revisit the plan, not to wait it out.
Booking
ParamedBook a trichology consultation — the doctor will run a trichoscopy and choose the protocol: ExoSignal Hair, cell-derived exosomes or a different solution.
Book a consultation →Exosomes — ExoCoBio, BENEV, Zishel, Promoitalia
ParamedCourse plan
ParamedThe manufacturer's protocol is at least 4 sessions at 10-day intervals, then maintenance every 2 months, with the schedule adapted to the degree of hair loss. Each session uses 1.5–2 ml of product, depending on the size of the thinning area. The first marker is less shedding after 4–6 weeks; objective progress in density is assessed on trichoscopy after 3–4 months, once new hair has grown out.
Comparison
ParamedCompared with Zishel Xomage H, the difference lies in the nature of the main active: Zishel uses exosomes from adipose-derived mesenchymal stem cells plus plant vesicles, while ExoSignal uses a synthetic exosomal structure plus PDRN and peptides. Compared with hair mesotherapy (Dermaheal HL, Dives Rich Hair), ExoSignal has a more complex composition and works not only nutritionally but through PDRN. Compared with PRP, the product is standardised, whereas plasma quality depends on the patient. The honest framing: in androgenetic alopecia this is part of a plan alongside baseline therapy, not a replacement for it; and in scarring alopecia follicle recovery should not be expected.
Contraindications
Paramed- ⚠️ Pregnancy and breastfeeding
- ⚠️ Cancer
- ⚠️ Active autoimmune disease
- ⚠️ Coagulation disorders or ongoing anticoagulant therapy
- ⚠️ Active inflammation, pustules or herpes in the treatment area
- ⚠️ Individual intolerance to any component of the product
Why Paramed
ParamedAt Paramed, ExoSignal Hair is prescribed after trichoscopy and, where needed, blood work — ferritin, vitamin D, thyroid hormones. The cause of the hair loss determines the protocol: sometimes exosomal products make sense straight away, sometimes deficiencies need closing and baseline therapy adding first. Your doctor will explain honestly that ExoSignal is a biomimetic system with PDRN rather than cell-derived exosomes, and will offer an alternative if one suits your case better.
Our doctors
Certified specialists at Paramed
Elvira Zakiyeva
Cosmetologist (MD)
15+ years' experience
2008 · Azerbaijan Medical University · +1 cert.
Languages: Russian, Azerbaijani
Elmira Jamalova
Cosmetologist (MD)
2009 · Tashkent Medical Academy · +2 cert.
Languages: Russian, Azerbaijani
Simona Muradova
Cosmetologist (MD)
2019 · Yaroslavl Medical University · +1 cert.
Languages: Russian, Azerbaijani
