Elvira Zakiyeva
Cosmetologist (MD)
15+ years' experience
2008 · Azerbaijan Medical University · +1 cert.
Languages: Russian, Azerbaijani
PDRN / PRDN Plinest · Newest · PhilArt Skin booster Course of 3–4 sessions
Polydeoxyribonucleotides (PDRN) for the face in Baku
Injections of purified DNA fragments from salmon or trout — a next-generation skin booster. They do not add volume or hydrate like biorevitalization: they restructure skin quality from within — density, elasticity, tone. At Paramed, we work with original Italian Plinest/Newest, Korean PhilArt, and Swiss Pluryal Silk.
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Overview
ParamedPolydeoxyribonucleotides (PDRN) — purified fragments of DNA extracted from the reproductive cells of salmon or trout. After injection into the dermis, they act as signaling molecules: activating fibroblasts, stimulating collagen and elastin production, improving microcirculation, and reducing inflammation through A2A receptors. Unlike hyaluronic acid, PDRN does not 'fill' the skin with water — it restructures its structure. Therefore, polydeoxyribonucleotides are referred to as bio-restructuring or next-generation skin boosters. At Paramed clinic in Baku, original products are used: Italian Plinest and Newest (Mastelli), Korean PhilArt (Croma-Pharma) with separate protocols for EYE/FACE/SCALP, and Swiss Pluryal Silk. Suitable for dull and dehydrated skin, early signs of aging, thin skin under the eyes, post-acne, and atrophy. Consultation is mandatory.
Benefits
Paramed- ✅ Skin restructuring: density, elasticity, even tone.
- ✅ Greatly helps with thin skin under the eyes and dark circles.
- ✅ Stimulates own collagen and elastin production.
- ✅ Anti-inflammatory effect — suitable for reactive skin and rosacea.
- ✅ Compatible with biorevitalization, Botox, and fillers in one course.
How it works
ParamedDuring the consultation, the doctor assesses the skin condition and selects the product: Plinest/Newest for the face and neck, PhilArt EYE for the under-eye area, PhilArt FACE for the face, Pluryal Silk for basic protocols. The product is injected with a fine needle using the micro-papule technique, nappage, or linear injection as indicated. The session lasts 30–45 minutes, and topical anesthesia is applied. The course consists of 3–4 procedures with an interval of 2–3 weeks. A maintenance session is recommended every 4–6 months.
Technology
ParamedPDRN consists of long chains of nucleotides (50–1500 kDa) derived from the DNA of fish reproductive cells (Oncorhynchus mykiss — trout, Oncorhynchus keta — chum salmon). After injection, they are broken down in the skin into short fragments that bind to A2A adenosine receptors on fibroblasts and keratinocytes. This activates the synthesis of collagen types I and III, fibroblast migration, and angiogenesis (new capillaries), while simultaneously suppressing pro-inflammatory cytokines. Unlike exosomes, the effect is achieved not through the transfer of growth factors but through receptor activation and incorporation of nucleotides into tissue repair. The effect is cumulative: visible thickening and improvement in tone increase over 2–3 months after the course.
- Source: DNA from trout/salmon, ultra-purified from proteins and allergens.
- Molecular weight: 50–1500 kDa (long chains of nucleotides).
- Mechanism: activation of A2A receptors on fibroblasts.
- Effects: collagenogenesis, angiogenesis, anti-inflammation.
- Cumulative effect — increases over 2–3 months after the course.
Preparation & aftercare
Paramed Before the procedure
- Avoid alcohol and blood-thinning medications (in agreement with the doctor) for 24 hours.
- Do not perform aggressive peels or facial hair removal for a week.
- Arrive without makeup or remove it before the procedure.
- If there is a history of herpes — prophylactic intake of acyclovir as per the scheme.
- Notify about allergies to fish and seafood — this is a contraindication.
- Inform about pregnancy, lactation, autoimmune, and oncological diseases.
After the procedure
- Do not wash your face or apply makeup for 12 hours.
- Use SPF 30+ daily for at least 2 weeks.
- Avoid saunas, baths, swimming pools, and intense workouts for 48 hours.
- Do not massage the face or use aggressive skincare for 5–7 days.
- Mild papules may occur at injection sites for 24–48 hours — this is normal and will resolve.
- Adhere to intervals between sessions.
FAQ
Paramed? How do polydeoxyribonucleotides differ from biorevitalization? ⌄
Biorevitalization with hyaluronic acid hydrates the skin — the main effect is through osmosis and hydration. Polydeoxyribonucleotides work deeper: they activate fibroblasts, restructure the collagen framework, and improve skin quality at a structural level. The effect is less 'instantaneous' but cumulative — it increases over 2–3 months.
? How does PDRN differ from exosomes? ⌄
These are different molecules and mechanisms. Exosomes are nanovesicles from stem cells that carry ready-made growth factors and microRNA. Polydeoxyribonucleotides are DNA fragments that activate A2A cell receptors. They are often prescribed sequentially or combined: PDRN for structure and density, exosomes for regeneration and anti-inflammation.
? Do polydeoxyribonucleotides help with dark circles under the eyes? ⌄
Yes, this is one of the key indications — especially PhilArt EYE. The thin skin under the eyes becomes denser, and the bluish tint from visible vessels decreases. Usually, 3–4 procedures with an interval of 3 weeks are required.
? Can they be combined with fillers and Botox? ⌄
Yes. PDRN works excellently in one program with fillers and Botox: it improves skin quality, while injectables relax facial expressions and restore volume. The order and intervals are tailored individually.
? How many procedures are needed? ⌄
The initial course consists of 3–4 sessions with an interval of 2–3 weeks. Maintenance procedures are recommended once every 4–6 months.
? Is there an allergy to fish DNA? ⌄
The products are ultra-purified from proteins and other allergens — reactions to fish are virtually non-existent. However, a history of seafood allergy is a relative contraindication; the decision is made by the doctor.
? Are there any contraindications? ⌄
Pregnancy and lactation, oncology, active phase autoimmune diseases, skin infections in the injection area, severe allergy to fish/seafood, blood clotting disorders. A complete list will be provided during the consultation.
Booking
Paramed Ready to start?
Schedule a consultation at Paramed clinic in Baku — the doctor will assess your skin condition and select the polydeoxyribonucleotide product: Plinest, Newest, PhilArt, or Pluryal Silk. Combination with biorevitalization, Botox, and fillers in one program is possible.
Injections — mesotherapy & biorevitalization
Paramed AZN Injections — mesotherapy & biorevitalization
Service
Price
PRP
Patient's autologous plasma with platelet concentrate. Universal rejuvenation of face, neck and hands; stimulates hair growth.
80 AZN
INNEA Aqua
Italy, Matex Lab. Biorevitalizer based on natural hyaluronic acid. Deep hydration, barrier restoration and skin radiance; suitable for all skin types and first-time biorevitalization.
200 AZN
Aquashine BR
Korea, Caregen. HA + 5 peptides, brightening profile. Biorevitalization for pigmentation, dull skin and uneven tone.
200 AZN
Aquashine PTX
Korea, Caregen. HA + peptides + polynucleotides. Enhanced anti-aging formula for mature skin and density.
220 AZN
Jalupro HMW
Switzerland, Professional Derma. High-molecular-weight HA + 4 amino acids (glycine, proline, lysine, leucine). Deep densification and fibroblast stimulation.
200 AZN
Restylane Vital
Sweden, Galderma. Stabilized HA via NASHA technology. Premium biorevitalization benchmark; course effect lasts up to 6 months.
300 AZN
Novacutan (Y-Bio / S-Bio)
Germany, Adoderm. Premium biorevitalization: Y-Bio (HA + 4 amino acids) or S-Bio (HA + succinic acid). Deep densification and anti-aging for face 35+. Course of 3–5 sessions.
340 AZN
Hyalual 1.1%
Switzerland, Hyalual Institute. HA + succinic acid, entry 1.1% concentration. For sensitive skin and first-time biorevitalization.
180 AZN
Hyalual 1.8%
Switzerland, Hyalual Institute. Universal 1.8% concentration — HA + succinic acid. Standard biorevitalization for face 30+.
200 AZN
Hyalual 2.2%
Switzerland, Hyalual Institute. Maximum 2.2% HA concentration with succinic acid. Pronounced densification and anti-aging for mature skin.
230 AZN
Teosyal PureSense Redensity I
Switzerland, Teoxane. HA + 8 amino acids + 3 antioxidants + vitamin B6 + lidocaine. Biorevitalization cocktail with built-in anaesthetic for face 25–35.
250 AZN
Jalupro
Switzerland, Professional Derma. Classic HA + 4 amino acids. Base biorevitalization protocol for face 25+.
180 AZN
NCTF 135 (3 ml)
France, Filorga. 53 active ingredients — vitamins, amino acids, antioxidants, minerals, coenzymes. Classic mesotherapy for dull and dehydrated skin.
150 AZN
NCTF 135 HA (3 ml)
France, Filorga. NCTF 135 + free hyaluronic acid. Enhanced hydration combined with the full nutrient complex.
180 AZN
Dermaheal Meso HSR
Korea, Caregen. Healthy Skin Recovery — anti-aging cocktail with growth factors and peptides. Smoothness and tone for face 30+.
60 AZN
Dermaheal Meso SB
Korea, Caregen. Skin Brightening — lightening cocktail with glutathione and kojic acid. For pigmentation, melasma and dull skin.
60 AZN
Dermaheal Eyebag Solution
Korea, Caregen. Targeted cocktail for under-eye bags and puffiness. Caffeine and peptides, drainage effect.
100 AZN
Dermaheal Dark Circle Solution
Korea, Caregen. Targeted cocktail for dark under-eye circles — addresses hemosiderin and pigmentation in thin skin.
100 AZN
Dermaheal HL
Korea, Caregen. Hair Loss — scalp mesotherapy. Against hair fall, for growth stimulation and density.
60 AZN
Lipolax — lipolytic (Korea)
Korea, Lipolax. Injection lipolytic based on phosphatidylcholine + deoxycholic acid. Localised fat reduction: double chin, flanks, abdomen, knees. Course of 2–4 sessions spaced 2–3 weeks apart.
100 AZN
Lipolab — lipolytic (Caregen, Korea)
Korea, Caregen Lipolab (PPC). Phosphatidylcholine-based injection lipolytic — disrupts fat-cell membranes. Target zones: double chin, flanks, banana fold, small localised fat deposits. Course of 2–4 sessions.
100 AZN
Exosomes for face — ExoCoBio ASCE+ SRLV
Premium flagship. Used in Oracle, Wonjin, Banobagi after laser resurfacing and microneedling.
480–550 AZN
Exosomes for face — ExoCoBio Exomage (sensitive skin, rosacea)
Anti-inflammatory profile; for rosacea, couperose and reactive skin.
500–580 AZN
Exosomes for face — BENEV
Premium; umbilical cord stem cell exosomes. Standard microneedling and RF partner.
450–520 AZN
Exosomes for face — standard kit
Accessible option for basic protocols and maintenance courses.
350–400 AZN
Polynucleotides (PDRN / PRDN) — Plinest (Mastelli, Italy)
Original Italian PDRN from trout DNA. Skin booster for density and skin quality.
380–450 AZN
Polynucleotides (PDRN / PRDN) — Newest (Mastelli)
Reinforced Plinest formula for mature skin and areas with marked atrophy.
420–480 AZN
Polynucleotides (PDRN / PRDN) — PhilArt EYE (under-eye)
Korea, Croma-Pharma. Special formula for thin under-eye skin — dark circles, wrinkles, thinning.
350–420 AZN
Polynucleotides (PDRN / PRDN) — PhilArt FACE
Standard face protocol: density, tone, post-acne, early signs of aging.
380–450 AZN
Polynucleotides (PDRN / PRDN) — Pluryal Silk
Switzerland, MD Skin Solutions. Accessible option for basic protocols and maintenance.
320–380 AZN
Our doctors
Certified specialists at Paramed
Elmira Jamalova
Cosmetologist (MD)
2009 · Tashkent Medical Academy · +2 cert.
Languages: Russian, Azerbaijani
Aybeniz Mamedli
Dermatologist (MD)
2017 · Donetsk National Medical University · +1 cert.
Languages: Russian, Azerbaijani
See also
Paramed
Paramed.az
