Polydeoxyribonucleotides (PDRN / PRDN) for the face — Plinest, Newest, PhilArt FACE

PDRN / PRDN Plinest · Newest · PhilArt Skin booster Course of 3–4 sessions

Polydeoxyribonucleotides (PDRN) for the face in Baku

Injections of purified DNA fragments from salmon or trout — a next-generation skin booster. They do not add volume or hydrate like biorevitalization: they restructure skin quality from within — density, elasticity, tone. At Paramed, we work with original Italian Plinest/Newest, Korean PhilArt, and Swiss Pluryal Silk.

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Overview

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Polydeoxyribonucleotides (PDRN) — purified fragments of DNA extracted from the reproductive cells of salmon or trout. After injection into the dermis, they act as signaling molecules: activating fibroblasts, stimulating collagen and elastin production, improving microcirculation, and reducing inflammation through A2A receptors. Unlike hyaluronic acid, PDRN does not 'fill' the skin with water — it restructures its structure. Therefore, polydeoxyribonucleotides are referred to as bio-restructuring or next-generation skin boosters. At Paramed clinic in Baku, original products are used: Italian Plinest and Newest (Mastelli), Korean PhilArt (Croma-Pharma) with separate protocols for EYE/FACE/SCALP, and Swiss Pluryal Silk. Suitable for dull and dehydrated skin, early signs of aging, thin skin under the eyes, post-acne, and atrophy. Consultation is mandatory.

Benefits

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✅ Skin restructuring: density, elasticity, even tone.
✅ Greatly helps with thin skin under the eyes and dark circles.
✅ Stimulates own collagen and elastin production.
✅ Anti-inflammatory effect — suitable for reactive skin and rosacea.
✅ Compatible with biorevitalization, Botox, and fillers in one course.

How it works

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During the consultation, the doctor assesses the skin condition and selects the product: Plinest/Newest for the face and neck, PhilArt EYE for the under-eye area, PhilArt FACE for the face, Pluryal Silk for basic protocols. The product is injected with a fine needle using the micro-papule technique, nappage, or linear injection as indicated. The session lasts 30–45 minutes, and topical anesthesia is applied. The course consists of 3–4 procedures with an interval of 2–3 weeks. A maintenance session is recommended every 4–6 months.

Technology

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PDRN consists of long chains of nucleotides (50–1500 kDa) derived from the DNA of fish reproductive cells (Oncorhynchus mykiss — trout, Oncorhynchus keta — chum salmon). After injection, they are broken down in the skin into short fragments that bind to A2A adenosine receptors on fibroblasts and keratinocytes. This activates the synthesis of collagen types I and III, fibroblast migration, and angiogenesis (new capillaries), while simultaneously suppressing pro-inflammatory cytokines. Unlike exosomes, the effect is achieved not through the transfer of growth factors but through receptor activation and incorporation of nucleotides into tissue repair. The effect is cumulative: visible thickening and improvement in tone increase over 2–3 months after the course.

Source: DNA from trout/salmon, ultra-purified from proteins and allergens.
Molecular weight: 50–1500 kDa (long chains of nucleotides).
Mechanism: activation of A2A receptors on fibroblasts.
Effects: collagenogenesis, angiogenesis, anti-inflammation.
Cumulative effect — increases over 2–3 months after the course.

Preparation & aftercare

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Before the procedure

Avoid alcohol and blood-thinning medications (in agreement with the doctor) for 24 hours.
Do not perform aggressive peels or facial hair removal for a week.
Arrive without makeup or remove it before the procedure.
If there is a history of herpes — prophylactic intake of acyclovir as per the scheme.
Notify about allergies to fish and seafood — this is a contraindication.
Inform about pregnancy, lactation, autoimmune, and oncological diseases.

After the procedure

Do not wash your face or apply makeup for 12 hours.
Use SPF 30+ daily for at least 2 weeks.
Avoid saunas, baths, swimming pools, and intense workouts for 48 hours.
Do not massage the face or use aggressive skincare for 5–7 days.
Mild papules may occur at injection sites for 24–48 hours — this is normal and will resolve.
Adhere to intervals between sessions.

FAQ

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? How do polydeoxyribonucleotides differ from biorevitalization? ⌄

Biorevitalization with hyaluronic acid hydrates the skin — the main effect is through osmosis and hydration. Polydeoxyribonucleotides work deeper: they activate fibroblasts, restructure the collagen framework, and improve skin quality at a structural level. The effect is less 'instantaneous' but cumulative — it increases over 2–3 months.

? How does PDRN differ from exosomes? ⌄

These are different molecules and mechanisms. Exosomes are nanovesicles from stem cells that carry ready-made growth factors and microRNA. Polydeoxyribonucleotides are DNA fragments that activate A2A cell receptors. They are often prescribed sequentially or combined: PDRN for structure and density, exosomes for regeneration and anti-inflammation.

? Do polydeoxyribonucleotides help with dark circles under the eyes? ⌄

Yes, this is one of the key indications — especially PhilArt EYE. The thin skin under the eyes becomes denser, and the bluish tint from visible vessels decreases. Usually, 3–4 procedures with an interval of 3 weeks are required.

? Can they be combined with fillers and Botox? ⌄

Yes. PDRN works excellently in one program with fillers and Botox: it improves skin quality, while injectables relax facial expressions and restore volume. The order and intervals are tailored individually.

? How many procedures are needed? ⌄

The initial course consists of 3–4 sessions with an interval of 2–3 weeks. Maintenance procedures are recommended once every 4–6 months.

? Is there an allergy to fish DNA? ⌄

The products are ultra-purified from proteins and other allergens — reactions to fish are virtually non-existent. However, a history of seafood allergy is a relative contraindication; the decision is made by the doctor.

? Are there any contraindications? ⌄

Pregnancy and lactation, oncology, active phase autoimmune diseases, skin infections in the injection area, severe allergy to fish/seafood, blood clotting disorders. A complete list will be provided during the consultation.

Booking

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Ready to start?

Schedule a consultation at Paramed clinic in Baku — the doctor will assess your skin condition and select the polydeoxyribonucleotide product: Plinest, Newest, PhilArt, or Pluryal Silk. Combination with biorevitalization, Botox, and fillers in one program is possible.

Polynucleotides (PDRN / PRDN)

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AZN Polynucleotides (PDRN / PRDN)

Service

Price

Polynucleotides (PDRN / PRDN) — Plinest (Mastelli, Italy)

Original Italian PDRN from trout DNA. Skin booster for density and skin quality.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Newest (Mastelli)

Reinforced Plinest formula for mature skin and areas with marked atrophy.

420–480 AZN

Polynucleotides (PDRN / PRDN) — PhilArt EYE (under-eye)

Korea, Croma-Pharma. Special formula for thin under-eye skin — dark circles, wrinkles, thinning.

350–420 AZN

Polynucleotides (PDRN / PRDN) — PhilArt FACE

Standard face protocol: density, tone, post-acne, early signs of aging.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Pluryal Silk

Switzerland, MD Skin Solutions. Accessible option for basic protocols and maintenance.

320–380 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Medium (Medixa, Italy)

PDRN 20 mg/ml + hyaluronic acid. Skin density and firmness, medium wrinkles and scars.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Strong (Medixa, Italy)

PDRN 25 mg/ml + hyaluronic acid 2 mg/ml. Deep regeneration: face, neck, décolletage, hands, body.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran Healer (PharmaResearch, Korea)

Pure polynucleotides from salmon DNA (DOT™). Flagship for all-round anti-aging, density and skin quality.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran I (under-eye) (PharmaResearch, Korea)

Formula for the periorbital area: dark circles, thin skin, under-eye wrinkles.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Rejuran S (PharmaResearch, Korea)

High viscosity, for post-acne scars and deep skin damage.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran HB (PharmaResearch, Korea)

Polynucleotides + non-crosslinked hyaluronic acid. Hydration with less discomfort, good for a first course.

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc 1.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, entry concentration. Biorevitalisation and skin quality.

320–380 AZN

Polynucleotides (PDRN / PRDN) — TwAc 2.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, reinforced formula. Density and tone across all skin layers.

350–420 AZN

Polynucleotides (PDRN / PRDN) — TwAc 3.0 (Yuma Medical, UK)

PDRN 10 mg/ml + hyaluronic acid 20 mg/ml. Deformational aging, hands, décolletage (30+).

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc Eyes (under-eye) (Yuma Medical, UK)

PDRN + hyaluronic acid for the under-eye area: dark circles, puffiness, fine lines.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Elare Red PN (U-Skin Lab, Korea)

Korea, U-Skin Lab. Salmon-DNA polynucleotide skin booster. Density, tone and quality of facial skin.

350–420 AZN

Polynucleotides (PDRN / PRDN) for hair — PhilArt SCALP

Korea, Croma-Pharma. Specialized scalp protocol: microcirculation, hair thickening.

300–380 AZN

Polynucleotides (PDRN / PRDN) for hair — Plinest (Mastelli)

Italian PDRN, off-label scalp protocol. Often paired with mesotherapy and PRP.

320–400 AZN

Polynucleotides (PDRN) — ADN Restart 2% (Mesopharm)

Russia, Mesopharm. Sodium deoxyribonucleotide 2% (salmon-milt DNA fragments under 450 kDa) with tripeptide-1 and a pH 7.0 buffer, 4 ml vial. Repair and anti-ageing work; delivered by injection.

$$$

Polynucleotides (PDRN) — NucleoSpire DNA-RNA 2% (Mesopharm)

Russia, Mesopharm. Polynucleotides at 20 mg/ml (2%) as salmon-milt DNA-RNA complexes plus non-stabilised hyaluronic acid 0.3%, in 1.3 ml and 4 ml vials. Intensive revitalisation, pigmentation work and recovery after aggressive procedures.

$$$

Polynucleotides (PDRN) — POLY-N Strong (Italy)

Italy. A polynucleotide gel at 25 mg/ml in a 2 ml syringe — one of the highest PDRN concentrations on the market. Mobilises fibroblasts to rebuild collagen and elastin; for marked loss of density and skin quality.

$$$